Andy Pettitte was born in 1972 in Baton Rouge, Louisiana. He attended Deer Park High School in Deer Park, Texas. There, he met his wife, Laura, and they have four children. Pettitte attended San Jacinto College North instead of going with the Yankees where he had been drafted in the 22nd round in 1990. In May of 1991, he did sign with the Yankees as an amateur.

Pettitte was sensational in his minor year career where he had a .98 ERA in his rookie year. He was signed by the Yankees and made his debut on April 29, 1995, where he would spend the next nine seasons as a starter. After the season in 2003, he signed a three year contract with the Houston Astros along with a $31.5 million salary. In 2004, he had a .226 batting average, but the season was cut short due to an elbow injury that lead to surgery. Pettitte helped to get the Astros to the World Series in 2005 with his 2.39 ERA and that turned out to be the best of his career.

After the 2006 season, Pettitte went back with the Yankees and signed for a one year, $16 million contract. Pettitte lost his first game of that season to Boston Red Sox in April of 2007. He won his 200th game on September 19, 2007. He ended up being the last starting pitcher for the Yankees at Yankee Stadium in September of 2008. We won the game against the Baltimore Orioles.